The susceptibility of AMR organisms to antimicrobial compounds is assessed in clinical and biomedical research settings through antimicrobial susceptibility testing (AST) methods, predominantly minimum inhibitory testing (MIC) and combination drug screening (CDS), which are particularly useful in the fight against antibiotic-resistant infections, such as urinary tract infections (UTIs) 6. aureus), have developed biological resistance to one or more of the worldвЂ™s essential first-line-of-defense antibiotic agents 4, 5. monocytogenes), and Staphylococcus aureus ( S. In the context of antibiotic resistance, for instance, more than 18 distinct bacteria, including pathogenic Escherichia coli ( E. Treatment of antimicrobial-resistant (AMR) infections places a significant economic burden on the worldwide economy, upwards of $35 billion per year in the United States alone, and is projected to be the cause of over 10 million deaths per year by year 2050 1, 2, 3. As such, this 3D Вµ-CGG platform has great potential to enable expedited combination AST screening for various biomedical and diagnostic applications. Furthermore, the antimicrobial effects of three highly clinically relevant antibiotic drugs, tetracycline, ciprofloxacin, and amikacin, were evaluated via experimental single-antibiotic minimum inhibitory concentration (MIC) and pairwise and three-way antibiotic combination drug screening (CDS) studies against model antibiotic-resistant Escherichia coli bacteria. The three-fluid gradient generation characteristics of the fabricated 3D Вµ-CGG prototype were quantified through both theoretical simulations and experimental validations. This work addresses this limitation by employing Multijet-3D-printed microchannel networks capable of fluidic routing in three dimensions to generate symmetric multidrug concentration gradients. Conventional Вµ-CGGs fabricated via photolithography-based micromachining processes, however, are fundamentally limited to two-dimensional fluidic routing, such that only two distinct antimicrobial drugs can be tested at once. Please note that our shipping incoterms are DAP (Delivered At Place).Microfluidic concentration gradient generators ( Вµ-CGGs) have been utilized to identify optimal drug compositions through antimicrobial susceptibility testing (AST) for the treatment of antimicrobial-resistant (AMR) infections. Generally, your order reaches your lab in only 2 to 3 days after we send it, no matter the destination! We try to offer you the best shipping rates and services, shipping all our orders through DHL Express. The shipping charges are calculated based on the weight of the package and the country of destination: you can estimate the shipping cost on the cart page. We ship worldwide from our warehouse in France. We can add the converted value in the required currency to the quote if requested. If you wish to pay in USD or GBP, please specify it in your PO. After receiving the quote, just send your purchase order at Our team will complete your purchase and send you the invoice!.Fill in the required informations, then click on Submit Quote.In the website header, click on Request a Quote.That's it! You will receive an order confirmation within a few minutes, and our team will send you the invoice.Complete your credit card informations (don't worry, we are using Stripe,В a PCI-certified program specialized in online transactions).In the cart page, click on Proceed to Checkout.Please note that some products are not available for direct purchase: just click 'Request a Quote' on the product page and fill in the form to get more informations! Credit card You can either order and pay via credit card or invoice (through a purchase order).

Gradient generator